| 发明名称 |
C1-SYMMETRIC BISPHOSPHINE LIGANDS AND THEIR USE IN THE ASYMMETRIC SYNTHESIS OF PREGABALIN |
| 摘要 |
<p>Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C<SUB>1</SUB>-symmetric bisphosphine ligands bound to transition metals.</p> |
| 申请公布号 |
PT1727620(E) |
申请公布日期 |
2007.11.05 |
| 申请号 |
PT20050708733T |
申请日期 |
2005.03.09 |
| 申请人 |
WARNER-LAMBERT COMPANY LLC |
发明人 |
JIAN BAO;VLADIMIR GENUKH BEYLIN;DEREK JOSEPH GREENE;GARRETT HOGE;WILLIAM SCOTT KISSEL;MARK EUGENE MARLATT;DEREK ANDREW PFLUM;HE-PING WU |
| 分类号 |
B01J31/24;C07B53/00;C07C227/32;C07C229/06;C07C229/08;C07C231/18;C07C233/47;C07C233/51;C07C253/30;C07C255/19;C07F9/50;C07F9/53;C07F9/54 |
主分类号 |
B01J31/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
