| 摘要 |
PROBLEM TO BE SOLVED: To provide a method, etc., for testing a cell degeneration control ability used in searching for a substance usable as an active ingredient of a drug for controlling the cell degeneration in a mammal. SOLUTION: The method for testing the cell degeneration control ability dependent on a transcriptional regulatory factor having an amino acid sequence such as an amino acid sequence, etc., which are represented by any of sequence numbers 1-3. The method for testing, etc., are characterized as comprising (1) a first step of bringing a test substance into contact with a mammalian cell expressing the transcriptional regulatory factor, (2) a second step of measuring an index value having a correlation with the presence or absence of phosphorylation of the transcriptional regulatory factor or a degree thereof in the mammalian cell after the first step and (3) a third step of evaluating the ability possessed by the test substance on the basis of the index value having the correlation with the presence or absence of the phosphorylation or the degree thereof measured in the second step. COPYRIGHT: (C)2008,JPO&INPIT
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