摘要 |
<p>[PROBLEMS] To provide a therapeutic or prophylactic agent for frequent urination/strong urge to urinate or incontinence associated with overactive bladder, a lower urinary tract disease accompanied by a lower urinary tract pain such as interstitial cystitis and chronic prostatitis or a disease accompanied by a pain, which acts based on excellent trkA receptor-inhibiting activity. [MEANS FOR SOLVING PROBLEMS] Disclosed is a novel azolecarboxamide derivative having an azole ring (e.g., a thiazole or oxazole ring) bound to a benzene, pyridine or pyrimidine ring through a carboxamide. It is confirmed that the azolecarboxamide derivative has a potent trkA receptor-inhibiting activity. It is found that the azolecarboxamide derivative can be used as a very efficient, safe therapeutic or prophylactic agent for a lower urinary tract disease or a disease accompanied by a pain.</p> |
申请人 |
ASTELLAS PHARMA INC.;SUGASAWA, KEIZO;KAWAGUCHI, KENICHI;MATSUZAWA, TAKAHO;SEO, RYUSHI;HARADA, HIRONORI;SUGA, AKIRA;ABE, TOMOAKI;AZAMI, HIDENORI;MATSUMOTO, SHUNICHIRO;SHIN, TAKASHI;TANAHASHI, MASAYUKI;WATANABE, TORU |
发明人 |
SUGASAWA, KEIZO;KAWAGUCHI, KENICHI;MATSUZAWA, TAKAHO;SEO, RYUSHI;HARADA, HIRONORI;SUGA, AKIRA;ABE, TOMOAKI;AZAMI, HIDENORI;MATSUMOTO, SHUNICHIRO;SHIN, TAKASHI;TANAHASHI, MASAYUKI;WATANABE, TORU |