Piperazinediones as Oxytocin Receptor Antagonists

摘要

Compounds of formula (I) wherein R₁ is 2-indanyl, R₂ is 1-methylpropyl, R₃ is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R₄ represents methyl and R₅ represents hydrogen or methyl or, R₄ and R₅ together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.