发明名称 |
METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 1 PROTEIN |
摘要 |
The invention is based on the discovery of the epitope in the Stxl protein for the 13C4 antibody. The invention features non-full length Stxl polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-Stxl antibodies specific for the 13C4 epitope of the Stxl protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection ) with a polypeptide that includes the 13C4 epitope or with an anti-Stxl antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stxl in a sample using the antibodies developed using the methods of the invention. |
申请公布号 |
WO2007124133(A2) |
申请公布日期 |
2007.11.01 |
申请号 |
WO2007US09799 |
申请日期 |
2007.04.20 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INCORPORATED;MELTON-CELSA, ANGELA;SMITH, MICHAEL;O'BRIEN, ALISON |
发明人 |
MELTON-CELSA, ANGELA;SMITH, MICHAEL;O'BRIEN, ALISON |
分类号 |
A61K38/00;A61P43/00;C07H21/04;C07K14/00;C07K16/00;C12N5/00;C12N5/02;C12N15/00;C12P21/04;C12P21/08;G01N33/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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