摘要 |
<p>A compound having the formula: (I), (II), (III), or (IV) wherein: R is an electron withdrawing or electron moiety; R<SUB>5</SUB> and R<SUB>10</SUB> may be the same or different and are a straight or branched 1-5 carbon or heteroatom chain substituted terminally by a cycloalkyl or aromatic ring, or other structural isomer or complex thereof; n is the position of substitution of R; Z is N-R<SUB>10</SUB>, O, S, S=O, CH<SUB>2</SUB> or C=O; y is 1-5 and Q is Z or NH, with the proviso that, where Z is NH, N-CH<SUB>3</SUB>, S or O and R<SUB>n</SUB> is H, R<SUB>5</SUB> may not be CH<SUB>3</SUB>; as well as quaternary ammonium salts thereof and their use as pharmacological compositions and for methods of treatment.</p> |