The present invention relates to the use of a composition comprising one or more early polypeptide(s) of human papillomavirus (HPV)-18 or a nucleic acid encoding one or more early polypeptide(s) of HPV-18 for the manufacture of a medicament for preventing or treating an infection or a pathological condition caused by at least one papillomavirus other than HPV-18. The invention is of very special interest in immunotherapy, in particular in preventing or treating HPV persistent infections possibly leading to cervical intraepithelial neoplasia (CIN) and ultimately to cervical cancer.
