发明名称 |
BIOPOLYMER SYSTEM FOR TISSUE SEALING |
摘要 |
A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises an alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide or both, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug. |
申请公布号 |
WO2007124198(A2) |
申请公布日期 |
2007.11.01 |
申请号 |
WO2007US62393 |
申请日期 |
2007.02.19 |
申请人 |
ENDOMEDIX, INC.;CHEN, WEILIAM;ABRAHAMS, JOHN, M. |
发明人 |
CHEN, WEILIAM;ABRAHAMS, JOHN, M. |
分类号 |
A61K51/00;A61K9/14;A61K38/18;A61K48/00 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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