<p>The present invention relates to droplet-based multiwell operations. One aspect of the present invention relates to droplet-based protein crystallization including embodiments related to a screening chip, an optimization chip, and a method of testing conditions for growing a crystal. Another aspect of the present invention relates to a droplet-based multiwell plate including embodiments related to a substrate including one or more input ports, a regular array of processing wells, and a network of droplet transport pathways that provide direct or indirect droplet transport from each of the input ports to each of the one or more processing wells. Yet another aspect of the present invention relates to a droplet-microactuator stamping platform including embodiments related to a stamping device comprising a droplet microactuator and a system regarding the same.</p>