发明名称 |
PROCESS FOR MANUFACTURING BISPHOSPHONIC ACIDS |
摘要 |
A manufacturing process for the preparation of bisphosphonic acids and in particular zoledronic acid is provided wherein diglyme, monoglyme, or a mixture thereof, is utilized to produce a homogenous, water soluble, solid reaction mass that upon cooling, dissolving in water and stripping results in a high purity product and comparatively good yield. wherein Ri is selected from the group consistin of |
申请公布号 |
WO2007109542(A3) |
申请公布日期 |
2007.11.01 |
申请号 |
WO2007US64176 |
申请日期 |
2007.03.16 |
申请人 |
ALBEMARLE CORPORATION;SAMSEL, EDWARD, G.;WU, TSE-CHONG |
发明人 |
SAMSEL, EDWARD, G.;WU, TSE-CHONG |
分类号 |
C07F9/6506 |
主分类号 |
C07F9/6506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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