发明名称 |
STABLE HYDROALCOHOLIC ORAL SPRAY FORMULATIONS AND METHODS |
摘要 |
<p>Stable formulations of an active pharmaceutical agent suitable for oral spray administration for absorption by the oral mucosa and related methods of preparation and administration of active pharmaceutical agent formulations are provided. Preferred embodiments of the invention provide formulations comprising an active pharmaceutical agent, a solvent, a buffer, and a viscosity modifying agent, wherein when a unit dose volume of about 25 to 400 mcL of the oral spray composition is sprayed, the spray has a median particle size diameter of about 40 to about 100 microns.</p> |
申请公布号 |
WO2007123955(A2) |
申请公布日期 |
2007.11.01 |
申请号 |
WO2007US09496 |
申请日期 |
2007.04.19 |
申请人 |
NOVADEL PHARMA INC.;BLONDINO, FRANK, E.;MALITZ, HOWARD |
发明人 |
BLONDINO, FRANK, E.;MALITZ, HOWARD |
分类号 |
A61K38/28;A61K9/12;A61K31/21;A61K31/405;A61K31/415;A61K31/5415;A61K31/70 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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