| 摘要 |
PROBLEM TO BE SOLVED: To provide a method, etc., for testing an apoptosis control ability which is useful in searching for a substance usable as an active ingredient of a drug for controlling the apoptosis in a mammal or a tissue or a cell thereof (hereinafter referred to as a mammal, etc.). SOLUTION: The method for testing the apoptosis control ability dependent on a transcription regulatory factor having an amino acid sequence, etc., composed of a plurality of specific sequences. The method for testing comprises (1) a first step of independently bringing a test substance into contact with both the mammal, etc., expressing the transcriptional regulatory factor and the mammal, etc., without substantially expressing the transcriptional regulatory factor, respectively, (2) a second step of measuring the presence, absence, etc., of activation of a glial cell in the mammals, etc., after the first step and (3) a third step of evaluating the ability possessed by the test substance on the basis of the presence, absence, etc., of the activation measured in the second step. COPYRIGHT: (C)2008,JPO&INPIT
|
