15 Beta-Substituted Steroids Having Selective Estrogenic Activity

摘要

The invention provides 15beta-substituted steroidal compounds having selective estrogen receptor activity according to Formula (I) wherein, R¹ is H, C_1-5 alkyl, C_1-12 acyl, di-(C_1-5 alkyl)aminocarbonyl, (C_1-5alkyl)oxycarbonyl or sulfamoyl, R² is H, C_1-3alkyl, C_2-3alkenyl or C_2-3alkynyl, each of which may be optionally substituted with a halogen, R³ is C_1-2alkyl, ethenyl or ethynyl, each of which may be optionally substituted with a halogen, and R⁴ is H or C_1-12 acyl.