发明名称 |
MEDICAMENTS |
摘要 |
The invention provides the use of an antagonist of CXCL 13 or CXCR5 activity in the preparation of a medicament for the prevention and/or inhibition of pathological scarring; as well as the use of such antagonists in the preparation of a medicament for the prevention and/or inhibition of fibrotic disorders; and the use of such antagonists in the preparation of a medicament for the prevention and/or treatment of a chronic wound. Medicaments or methods of the invention are particularly suitable for use in keloids or venous ulcers. Suitable antagonists of CXCL1 3 or CXCR5 activity may be any compound capable of inhibiting the CXCL13/CXCR5 signalling pathway. The invention also provides a model of aberrant wound healing, which may lead to pathological scar formation, or to chronic wound formation. |
申请公布号 |
CA2649522(A1) |
申请公布日期 |
2007.11.01 |
申请号 |
CA20072649522 |
申请日期 |
2007.04.20 |
申请人 |
RENOVO LIMITED |
发明人 |
FERGUSON, MARK WILLIAM JAMES;O'KANE, SHARON;FRENCH, NEIL;HODGSON, DARREN;OCCLESTON, NICHOLAS |
分类号 |
A61K38/19;A01K67/00;A61K31/70;A61K39/395;A61P17/02 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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