| 摘要 |
Compounds of Formula (I), are provided where T is CHO, COR<SUB>8</SUB>, or C(OH)R<SUB>1</SUB>R<SUB>2</SUB>; R<SUB>1 </SUB>and R<SUB>2 </SUB>are hydrogen, optionally substituted lower alkyl, CF<SUB>3</SUB>, optionally substituted alkenyl, or optionally substituted alkynyl; R<SUB>3 </SUB>is hydrogen or optionally substituted lower alkyl; R<SUB>4 </SUB>is (CF<SUB>3</SUB>)<SUB>n</SUB>alkyl, (CF<SUB>3</SUB>)<SUB>n</SUB>(substitutedalkyl), (CF<SUB>3</SUB>)<SUB>n</SUB>alkylphenyl, (CF<SUB>3</SUB>)<SUB>n</SUB>alkyl(substitutedphenyl), or (F)<SUB>n</SUB>cycloalkyl; n=1-3; R<SUB>5 </SUB>is hydrogen, halogen, CF<SUB>3</SUB>, diene fused to Y when Y-C, or substituted diene fused to Y when Y-C; W, Y and Z are C, CR<SUB>6 </SUB>or N where at least one of W, Y or Z are C; R<SUB>6 </SUB>is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO<SUB>2</SUB>, or NR<SUB>7</SUB>; R<SUB>7 </SUB>is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R<SUB>8 </SUB>is lower alkyl, CF<SUB>3</SUB>, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.
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