发明名称 |
BACTERIAL GLYCOLIPID ACTIVATION OF CD1D-RESTRICTED NKT CELLS |
摘要 |
<p>Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.</p> |
申请公布号 |
EP1848813(A2) |
申请公布日期 |
2007.10.31 |
申请号 |
EP20060733921 |
申请日期 |
2006.01.26 |
申请人 |
BRIGHAM YOUNG UNIVERSITY;THE SCRIPPS RESEARCH INSTITUTE;THE UNIVERSITY OF CHICAGO |
发明人 |
TEYTON, LUC;BENDELAC, ALBERT;SAVAGE, PAUL |
分类号 |
A61K35/74;A61K39/39 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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