发明名称 |
METHOD AND KIT FOR DETECTING PROLIFERATIVE DISEASES CAUSING SCLEROSIS, PREVENTIVE AND/OR REMEDY FOR PROLIFERATIVE DISEASES CAUSING SCLEROSIS AND METHOD AND KIT FOR IDENTIFYING SUBSTANCE EFFICACIOUS IN PREVENTING AND/OR TREATING PROLIFERATIVE DISEASES CAUSING SCLEROSIS |
摘要 |
A method of detecting proliferative diseases causing sclerosis, comprising measuring the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1, phosphorylated Smad1, activin receptor-like kinase 1, activin receptor-like kinase 3 and bone morphogenetic proteins in a biological sample. A kit therefor. A prophylactic and/or therapeutic agent for proliferative diseases causing sclerosis, comprising as an active ingredient a substance having an inhibitory effect on the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A method of identifying substances effective in preventing and/or treating proliferative diseases causing sclerosis, comprising judging whether or not a test substance inhibits the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A kit therefor. |
申请公布号 |
EP1672062(A4) |
申请公布日期 |
2007.10.31 |
申请号 |
EP20040787788 |
申请日期 |
2004.09.09 |
申请人 |
HUBIT GENOMIX, INC.;DOI, TOSHIO;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
DOI, TOSHIO;ABE, HIDEHARU |
分类号 |
C12N15/00;A61K45/00;A61K45/06;A61P13/12;A61P43/00;C12Q1/68 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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