ANTI-T CELL AND AUTOANTIGEN TREATMENT OF AUTOIMMUNE DISEASE
摘要
<p>The invention is directed to a new method for the treatment of new onset Type I diabetes in mammals or for the treatment of pre-Type I diabetic mammals where the method comprises administering (a) anti-T cell therapy to the mammal and administering (b) an autoantigen and optional mucosal antigen composition, wherein (a) and (b) are administered concurrently or sequentially Exemplified is a treatment using a mixture of anti-CD3 antibodies, a glutamic acid decarboxylase (GAD) autoantigen, and an immunoregulatory cytokine Canme GAD sequences are also disclosed.</p>
申请公布号
EP1848806(A1)
申请公布日期
2007.10.31
申请号
EP20060701862
申请日期
2006.02.06
申请人
DOW AGROSCIENCES LLC;PLANTIGEN INC.
发明人
JEVNIKAR, ANTHONY;MA, SHENGWU;AINLEY, WILLIAM, MICHAEL;MERLO, DONALD JOSEPH;RUSSELL, SEAN, MICHAEL;ARMSTRONG, JANNA, M.