发明名称 |
Photostabilized topical formulations of ketoprofen containing two UV filters |
摘要 |
The invention relates to topical pharmaceutical formulations containing ketoprofen or its S(+) isomer dexketoprofen or mixtures of the two isomers, together with two UV filters, preferably octyl methoxy cinnamate and phenyl benzimidazol sulphonic acid, and an antioxidant, preferably butyl hydroxy toluene (BHT). The formulations enable a photostability of the active principle, have no, or very low, irritant effect on the skin, are well tolerated, and present an adequate penetration through the skin. |
申请公布号 |
ZA200508153(B) |
申请公布日期 |
2007.10.31 |
申请号 |
ZA20050008153 |
申请日期 |
2005.10.10 |
申请人 |
BERLIN-CHEMIE AKTIENGESELLSCHAFT MENARINI RICERCHE S.P.A. |
发明人 |
GROEGER, KARSTEN;MAGGI, CARLO ALBERTO;MANZINI, STEFANO;SCHMITZ, REINHARD;WIHSMANN, MARC |
分类号 |
A61K;A61K9/06;A61K31/192;A61K47/14;A61K47/20;A61P;A61P19/00;A61P29/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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