发明名称 |
MONOCLONAL ANTIBODIES AGAINST CD30 LACKING IN FUCOSYL RESIDUES |
摘要 |
<p>The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.</p> |
申请公布号 |
EP1848745(A2) |
申请公布日期 |
2007.10.31 |
申请号 |
EP20060720888 |
申请日期 |
2006.02.17 |
申请人 |
MEDAREX, INC. |
发明人 |
CARDARELLI, JOSEPHINE, M.;BLACK, AMELIA, NANCY |
分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|