发明名称 |
2,3-dihydro-6-nitroimidazo (2,1-B) oxazole compounds for the treatment of tuberculosis |
摘要 |
The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria. |
申请公布号 |
ZA200602184(B) |
申请公布日期 |
2007.10.31 |
申请号 |
ZA20060002184 |
申请日期 |
2004.10.29 |
申请人 |
OTSUKA PHARMACEUTICAL CO. LTD. |
发明人 |
TSUBOUCHI, HIDETSUGA;SASAKI, HIROFUMI;ITOTANI, MOTOHIRO;HARAGUCHI, YOSHIKAZU;MIYAMURA, SHIN;MATSUMOTO, MAKOTO;HASHIZUME, HIROYUKI;TOMISHIGE, TATSUO;KAWASAKI, MASANORI;OHGURO, KINUE;SUMIDA, TAKUMI;HASEGAWA, TAKESHI;TANAKA, KAZUHO;TAKEMURA, ISAO |
分类号 |
A61K;A61P;C07D |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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