Substituerte arylpyraziner, anvendelse av slike for fremstilling av farmasoytisk preparat for behandling av sykdom, metode for a lokalisere CRF-reseptorer i vevsnittprover basert pa slike forbindelser, anvendelse av forbindelsene for a hemme, endre eller modulere reseptorfunksjoner, farmasoytisk preparat og pakket farmasoytisk prparat inneholdende disse forbindelsene.

摘要

Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF₁ receptors, including human CRF₁ receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF₁ receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.