发明名称 |
COMPOUNDS AND METHODS FOR THIOL-CONTAINING COMPOUND EFFLUX AND CANCER TREATMENT |
摘要 |
Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e., ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport. |
申请公布号 |
WO2007073518(A3) |
申请公布日期 |
2007.10.25 |
申请号 |
WO2006US60941 |
申请日期 |
2006.11.15 |
申请人 |
NATIONAL JEWISH MEDICAL AND RESEARCH CENTER;DAY, BRIAN J.;KACHADOURIAN, REMY |
发明人 |
DAY, BRIAN J.;KACHADOURIAN, REMY |
分类号 |
C07D233/70;A61K31/35;A61K31/353;A61K31/37;A61K31/403;A61K31/4152;A61K31/4166;A61K31/421;A61K31/425;A61K31/428;A61K31/47;A61K31/52;A61K31/635;A61P11/00;A61P35/00;C07D209/86;C07D233/54;C07D261/08;C07D263/32;C07D277/24;C07D473/00 |
主分类号 |
C07D233/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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