AN OPTICAL APPARATUS FOR SIMULTANEOUSLY MEASURING THE SCATTERING AND CONCENTRATION SIGNALS OF MACROMOLECULES IN A FLOW CELL
摘要
<p>This invention relates to a fiber optic apparatus for simultaneously measuring the scattering and concentration signals of macromolecules in a flow cell 3. The apparatus is based on the delivery/focusing of both a laser and ultraviolet light source to the same physical position in a low volume flow cell 4, via a bifurcated optical fiber 3. This configuration allows the light scattering and concentration signal changes associated with a macromolecular solution passing through the flow channel to be measured simultaneously. This invention also relates to a method that uses the optical apparatus 10 to determine properties of a macromolecular solution such as the ideal crystallization and/or formulation conditions (via B<SUB>22</SUB>) for a given protein solution.</p>
申请公布号
WO2007121363(A2)
申请公布日期
2007.10.25
申请号
WO2007US66647
申请日期
2007.04.13
申请人
MISSISSIPPI STATE UNIVERSITY;WILSON, W. WILLIAM;FANGUY, JOSEPH C.;HOLMAN, STEVEN;GUO, BIN
发明人
WILSON, W. WILLIAM;FANGUY, JOSEPH C.;HOLMAN, STEVEN;GUO, BIN