Homogeneously formulating microdosed active principles

摘要

A microdose of at least one active principle is essentially homogeneously formulated within at least one excipient therefor, via the following steps: 1. weighing the at least one active principle in a receptacle lined with a petroleum jelly; 2. encapsulating the active principle with additional petroleum jelly; 3. introducing the receptacle confining the active principle(s) and the petroleum jelly into a mixer, the receptacle being provided with perforations of a size and shape as to permit diffusion of the active principle(s) and petroleum jelly therethrough and the mixer containing at least one excipient in heated liquid state; and 4. melting said petroleum jelly by immersion of the receptacle within the at least one excipient in heated liquid state and thence diffusing and microdosing the active principle(s) therein.