| 摘要 |
A phyto-pharmacological substance, namely a saponin, precursor or derivative, with emulsifying/detergent/surfactant/fat dissolving properties administered into the systemic circulation of a subject via a variety of routes of administration including the topical-dermatological such as a skin patch, the oral-digestive in association with solubility or permeability or stability enhancers, alone or in synergitic combination, the topical-mucous membrane administration such as the sublingual route, the intravenous, subcutaneous, rectal, intramuscular, intradermal, inhalatory in form of inhaled microcrystals, the intrarterial, the saponin substance reaching and dissolving with its emulsifying properties the cholesterol aggregates and in general the lipidic core within the atherosclerotic plaque. As a result of this phyto-pharmacological direct action upon the atherosclerotic plaque by the phytocompound resulting in the dissolution of the cholesterol aggregates of the plaque, the plaque is no longer vulnerable to rupture and arterial flow is restituted to physiological values present prior to plaque formation. This effect on the lipid core of the plaque by the saponin is expected to reduce and/or eliminate altogether preexisting atherosclerotic lesions and significantly reduce chances of acute and chronic ischemic events.
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