| 摘要 |
The application relates to the field of suicide gene therapy using expression vectors encoding a deoxynucleotide kinase capable of converting prodrugs into cytotoxic drugs. In particular, Chicken deoxycytidine kinase and eukaryotic deoxyadenosine kinase polypeptides and nucleotides encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides for the treatment of malignancies and viral infections, methods of sensitising cells to prodrugs, and methods of inhibiting pathogenic agents in warm-blooded animals using said dCKs and dAKs.
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