| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound useful as an NO-production accelerator and/or eNOS (endothelial NO-synthesizing enzyme) activator. SOLUTION: This phenethyl-nicotinamide derivative which is an active ingredient of a medicine has a blood stream circulation-improving effect by its excellent blood vessel endothelial NO production acceleration and/or eNOS-activation activity, and further has platelet agglutination inhibition, anti-thrombotic effect, anti-proliferation effect, anti-inflammatory effect, etc. The disclosed medicine is useful for improving diseases or pathological states having causes of blood vessel endothelium function failure caused by the reduction of the blood vessel endothelial NO production and/or the reduction of the eNOS function, and especially useful as the treating agent of diseases such as circulation failure, etc., such as peripheral artery obstructive disease (PAOD), arteriosclelosis, ischemic heart failure, etc. COPYRIGHT: (C)2008,JPO&INPIT
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