| 摘要 |
The present invention relates to a urea derivative or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect. A urea derivative having the formula: [wherein R<SUP>1 </SUP>is a C<SUB>6</SUB>-C<SUB>10 </SUB>aryl group which may be independently mono- to pentasubstituted by a group selected from Substituent Group a or others; R is a C<SUB>6</SUB>-C<SUB>10 </SUB>aryl group which may be independently mono- to pentasubstituted by a group selected from Substituent Group a or others; E is a group having the formula (II) or the formula (III) (wherein R<SUP>3 </SUP>is a hydrogen atom or others; R<SUP>4 </SUP>and R<SUP>5</SUP>, which are the same or different, are a hydrogen atom or others; X and U, which are the same or different, are a group represented by the formula CH or others; m and n, which are the same or different, are I or another number) or others; and A is a group represented by the formula -NH-C(-O)- or others], or a pharmacologically acceptable salt thereof.
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