发明名称 |
ATTENUATED HUMAN PARAINFLUENZA VIRUS, METHODS AND USES THEREOF |
摘要 |
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein. |
申请公布号 |
CA2605878(A1) |
申请公布日期 |
2007.10.25 |
申请号 |
CA20062605878 |
申请日期 |
2006.01.10 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRE TAR |
发明人 |
COLLINS, PETER L.;NOLAN, SHEILA;MURPHY, BRIAN R.;SKIADOPOULOS, MARIO H. |
分类号 |
C12N7/00 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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