METHOD OF NITRATION

摘要

PROBLEM TO BE SOLVED: To provide a method of industrially advantageously producing an N-nitroisourea or a salt thereof useful for a synthetic intermediate for medicines and pesticides. SOLUTION: The method of producing a compound represented by the formula (2) or a salt thereof comprises a step of reacting a compound represented by the formula (1) or a salt thereof with a nitrating agent in the presence of sulfur trioxide. In formula (1), R1represents an optionally substituted linear or branched 1-6C alkyl group; R2and R3may be the same or different and each independently represents an optionally substituted linear or branched 1-6C alkyl group, a cycloalkyl group or a substituted aryl group, provided that only one of R2and R3does not represent a hydrogen atom. In formula (2), R1, R2and R3are as defined above. COPYRIGHT: (C)2008,JPO&INPIT