| 发明名称 |
NOVEL HCV NON-STRUCTURAL POLYPEPTIDE |
| 摘要 |
Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupt the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed. |
| 申请公布号 |
EP1233982(B1) |
申请公布日期 |
2007.10.24 |
| 申请号 |
EP20000989206 |
申请日期 |
2000.11.22 |
| 申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
COIT, DORIS;MEDINA-SELBY, ANGELICA;SELBY, MARK;HOUGHTON, MICHAEL |
| 分类号 |
C07K14/18;C12N15/09;A61K39/00;A61K39/29;A61K39/295;A61P31/12;C07K16/08;C07K16/10;C12N1/19;C12N5/10;C12N15/51;C12N15/62;C12N15/85;C12P21/02;C12P21/08 |
主分类号 |
C07K14/18 |
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