<p>Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a DNA sequence which is expressed by the cell and which codes for a protein having complement inhibitory activity and which provides protection against complement-based lysis, i.e. hyperacute rejection. In addition, the cell's natural genome is changed so that proteins encoded by the class I or class II major histocompatability complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.
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申请公布号
EP1041142(A3)
申请公布日期
2007.10.24
申请号
EP20000114262
申请日期
1992.07.14
申请人
OKLAHOMA MEDICAL RESEARCH FOUNDATION;YALE UNIVERSITY
发明人
SIMS, PETER J.;BOTHWELL, ALFRED L.M.;ELLIOT, EILEEN A.;FLAVELL, RICHARD A.;MADRI, JOSEPH;ROLLINS, SCOTT, DR.;BELL, LEONARD;SQUINTO, STEPHEN