| 摘要 |
Embedder compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes an embedder peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the embedder peptide converts to a non-ionic lipophilic form effective to embed into membranes of cells. Each composition also includes a cargo component which cannot be pulled across cell membranes by the embedder peptide and which is effective for detecting or killing cells in whose membranes the embedder peptide has embedded.
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