发明名称 |
Mutant forms of cholera holotoxin as an adjuvant |
摘要 |
Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
|
申请公布号 |
US7285281(B2) |
申请公布日期 |
2007.10.23 |
申请号 |
US20030478307 |
申请日期 |
2003.12.04 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYCORPORATE |
发明人 |
GREEN BRUCE A.;HOLMES RANDALL K.;JOBLING MICHAEL G.;ZHU DUZHANG |
分类号 |
A61K39/106;C12N15/09;A61K39/00;A61K39/002;A61K39/008;A61K39/02;A61K39/095;A61K39/102;A61K39/12;A61K39/245;A61K39/35;A61K39/39;A61P35/00;C07K14/185;C07K14/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02 |
主分类号 |
A61K39/106 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|