发明名称 |
Smooth muscle growth inhibitory composition, diagnostic method for arteriosclerosis, and kit therefor |
摘要 |
The invention provides not only a smooth muscle growth inhibitory composition and a composition for inhibiting expression of adhesion molecules in vascular endothelial cells, each comprising the adipose tissue-specific secretory factor apM1 as an active ingredient, but also a method for diagnosis of arteriosclerosis which comprises assaying apM1 in a sample, an antibody against apM1, and a diagnostic kit for arteriosclerosis which comprises the antibody as an active component, all of which contribute to the elucidation of obesity-related genes and corresponding expression products which are useful for the etiologic exploration and establishment of therapeutic modalities for various obesity-related diseases, particularly arteriosclerosis inclusive of angina pectoris and myocardial infarction. By utilizing the information thus obtained, therapeutic and diagnostic methods for various diseases can be established.
|
申请公布号 |
US7285275(B2) |
申请公布日期 |
2007.10.23 |
申请号 |
US20050097334 |
申请日期 |
2005.04.04 |
申请人 |
OTSUKE PHARMACEUTICAL CO., LTD. |
发明人 |
MATSUZAWA YUJI;OHMOTO YASUKAZU |
分类号 |
A61K38/16;A61K38/00;A61K38/17;A61K38/22;A61K38/27;C07K1/12;C07K14/575;C07K16/18;C07K16/26;C12P21/08;G01N33/50;G01N33/68 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|