发明名称 |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
摘要 |
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. Used alone, or in conjunction with other antisense oligonucleotides, these compositions inhibit the proliferation of FL cancer cells.
|
申请公布号 |
US7285288(B1) |
申请公布日期 |
2007.10.23 |
申请号 |
US19970381747 |
申请日期 |
1997.10.03 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
TORMO MAR;TARI ANA M;LOPEZ-BERESTEIN GABRIEL;MCDONNELL TIMOTHY J |
分类号 |
C12Q1/68;C07H21/02;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|