| 摘要 |
A novel pyrimidine nucleoside compound, or its salt, of the general formula: (1) wherein one of X and Y is a cyano while the other is a hydrogen atom; and one of R1 and R2 is a hydrogen atom, a carbonyl having an alkyl monosubstituted with amino, or a group of the formula (R3)(R4)(R5)Si-while the other is a silyl of the formula (R6)(R7)(R 8)Si-, or alternatively R1 and R2 together represent a group of the formula-Si(R9)(R10)-and may form a six-membered cyclic group, provided that each of R3, R4, R5, R6, R7 and R 8 is an alkyl, a cycloalkyl, an aryl or an alkyl substituted with one or two aryls, and that R9 and R10 are alkyls. The provided novel pyrimidine nucleoside compounds exhibit antitumor efficacy higher than those of conventional pyrimidine nucleoside compounds.
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