POLYNUCLEOTIDES COMPRISING SINGLE NUCLEOTIDE POLYMORPHISM, MICROARRAYS AND DIAGNOSTIC KITS COMPRISING THE SAME, AND METHODS FOR DIAGNOSING PREMATURE OVARIAN FAILURE USING THE SAME

摘要

A polynucleotide including single nucleotide polymorphism(SNP) derived from LAMC1 (Laminin, gamma 1) or a complementary polynucleotide thereof is provided to be used as a clinical diagnosis marker of premature ovarian failure(POF). A polynucleotide or a complementary nucleotide thereof is at least one selected from the group consisting of a polynucleotide(b) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 2 and has a 201st base(polymorphism) of C; a polynucleotide(d) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 4 and has a 201st base(polymorphism) of C; a polynucleotide(e) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 5 and has a 222nd base(polymorphism) of T; a polynucleotide(f) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 6 and has a 767th base(polymorphism) of G; a polynucleotide(g) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 7 and has a 767th base(polymorphism) of G; a polynucleotide(j) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 10 and has a 201st base(polymorphism) of A; a polynucleotide(k) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 11 and has a 501st base(polymorphism) of T; and a polynucleotide(l) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 12 and has a 201st base(polymorphism) of T.