COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

摘要

The alleged invention relates to indole derivatives according to formula 1, namely, wherein X is CH<SUB>2</SUB>, O, NR<SUP>2</SUP> or NOR<SUP>2</SUP> and wherein A is preferably a six membered ring involving a nitrogen heteroatom. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.