摘要 |
<p>The present invention relates generally to the fields of gene therapy, immunology, and vaccine technology. More specifically, the invention relates to a novel system that can rapidly generate high titers of adenovirus vectors that are free of replication-competent adenovirus (RCA). Also provided are methods of generating these RCA-free adenoviral vectors, immunogenic or vaccine compositions comprising these RCA-free adenovirus vectors, methods of expressing a heterologous nucleic acid of interest in these adenovirus vectors and methods of eliciting immunogenic responses using these adenovirus vectors.</p> |
申请人 |
VAXIN, INC.;TANG, DE-CHU, C.;ZHANG, JIANFENG;VAN KAMPEN, KENT, R. |
发明人 |
TANG, DE-CHU, C.;ZHANG, JIANFENG;VAN KAMPEN, KENT, R. |