PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE

摘要

The invention relates to pyrimidines suitable as substrates for O⁶-alkylguanine-DNA alkyltransferases (AGT) of formula (I) wherein R¹ is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido; R² is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from pyrimidines of formula (I) to O⁶-alkylguanine-DNA alkyltransferases (AGT) and AGT fusion proteins.