摘要 |
An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection array that includes a plurality of microprojections that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection array having a plurality of array regions, each of the array regions having a different biocompatible coating disposed thereon, wherein at least one of the array region coatings includes an immunologically active agent. In one embodiment, each coating on the array regions includes a different immunologically active agent. In another embodiment, the biocompatible coating on a first array region includes an immunologically active agent and the biocompatible coating on a second array region includes an immune response augmenting adjuvant. |
申请人 |
ALZA CORPORATION;TRAUTMAN, JOSEPH, C.;DADDONA, PETER, E.;CORMIER, MICHEL, J., N. |
发明人 |
TRAUTMAN, JOSEPH, C.;DADDONA, PETER, E.;CORMIER, MICHEL, J., N. |