Y134.5 DEFICIENT HSV COMPRISING A CODING REGION OF A MEMBER OF THE MAPK PATHWAY FOR THE TREATMENT OF A CELL PROLIFERATION DISORDER
摘要
The invention provides materials and methods for the identification of cells exhibiting a cell proliferative disorder that are amenable to treatment with a herpes simplex virus that does not express an approximately wild-type level of ICP34.5. Also provided are methods of treating cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.
申请公布号
WO2007087580(A3)
申请公布日期
2007.10.18
申请号
WO2007US61002
申请日期
2007.01.24
申请人
THE UNIVERSITY OF CHICAGO;SMITH, KERRINGTON, D.;MEZHIR, JAMES, J.;WEICHSELBAUM, RALPH, R.;ROIZMAN, BERNARD
发明人
SMITH, KERRINGTON, D.;MEZHIR, JAMES, J.;WEICHSELBAUM, RALPH, R.;ROIZMAN, BERNARD