<p>The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti- microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.</p>
申请公布号
WO2007117639(A2)
申请公布日期
2007.10.18
申请号
WO2007US08647
申请日期
2007.04.06
申请人
THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE;MYERS, ANDREW, G.;BRUBAKER, JASON, D.;SUN, CUIXIANG;WANG, QIU