FACTOR XA INHIBITOR INCLUSION COMPLEX WITH CYCLODEXTRIN

摘要

An injectable Factor Xa inhibitor formulation is provided which includes the Factor Xa inhibitor razaxaban or apixaban, a solubilizing agent which is a substituted ß-cyclodextrin, preferably, sulfobutyl ether ß-cyclodextrin (SBE-CD) or hydroxypropyl-ß-cyclodextrin (HPB-CD), and water. A method for preventing or treating venous thrombosis, deep venous thrombosis and acute coronary syndrome employing the above formulation is also provided.