PRODER P 1 EXPRESSED IN A PROKARYOTIC CELL

摘要

This invention relates to novel methods for producing hypoallergenic recombinant derivatives of ProDer p 1, the precursor form of the major protein allergen from Dermatophagoides pteronyssinus Der p 1, and to the derivatives produced by such methods. The invention further relates to the use of said hypoallergenic recombinant ProDer p 1 derivatives in formulating immunogenic compositions and vaccines effective in the prevention and/ or the reduction of allergic responses to specific allergens. The invention also relates to novel ProDer p 1 protein and nucleic acid sequences.