METHODS AND APPARATUSES FOR SELECTION AND/OR PROCESSING OF PARTICLES, IN PARTICULAR FOR SELECTIVE AND/OR OPTIMIZED LYSIS OF CELLS

摘要

Methods and apparatus for the selection or processing of particles sensitive to the application of an external stimulus, in which is produced, by applying the external stimulus, the rupture/lysis of at least one selected particle or the fusion of first and second selected particles, by means of the organisation of the particles (CELL) using a first field of force (FMAN) by selectively energising electrodes (EL) of an array of selectable electrodes having dimensions comparable to or smaller than those of the particles, applying to the electrodes a first configuration (PMAN) of stresses; and by applying to the electrodes a second configuration (PZAP) of stresses, so as to create a second field of force (FZAP), located substantially close to at least one selected particle to be lysated (CELL) or to a pair of first and second particles to be fused and such as to produce the application of a stimulus suited to produce their lysis or fusion.