The present invention relates to polynucleotide and polypeptide sequences which are associated with eosinophil mediated inflammatory diseases, such as asthma. The invention also relates to means and methods for modulating the expression and/or activity of these sequences, preferably in the treatment or prevention of inflammatory disease mediated by eosinophils. Screening assays for agents which act as agonists or antagonists of these polynucleotides or polypeptides are also provided.
