摘要 |
The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E. C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitriles. |
申请人 |
B.R.A.I.N. AG;ECK, JUERGEN;LIEBETON, KLAUS;FISCHER, LUTZ;LUTZ-WAHL, SABINE;HENSEL, MARTINA;EWERT, CHRISTIAN;WAELZ, MARCUS |
发明人 |
ECK, JUERGEN;LIEBETON, KLAUS;FISCHER, LUTZ;LUTZ-WAHL, SABINE;HENSEL, MARTINA;EWERT, CHRISTIAN;WAELZ, MARCUS |